The Journal of Immunology, Vol 131, Issue 3 1554-1557, Copyright © 1983 by American Association of Immunologists

ARTICLES

Ocular herpes simplex virus infection is diminished by depletion of B lymphocytes

C Jordan, S Baron, F Dianzani, J Barber and GJ Stanton

Rabbit anti-mouse mu-chain serum was used to deplete specifically IgM- bearing B cells and B cell function in BALB/c mice. B cell-depleted and normal littermates were infected via the cornea with herpes simplex virus type 1 (HSV-1) at 4 to 5 wk of age. B cell-depleted mice had a reduced number of lymphocytes bearing surface immunoglobulin and a greatly reduced ability to produce antibody. Mortality was reduced from 89% in normal controls to 42% in B cell-depleted mice (p less than 0.001) and peak virus shedding from eyes was also reduced as much as 90% in the B cell-depleted mice (p less than or equal to 0.0005). These results support the hypothesis that a B cell function of normal mice somehow contributes directly or indirectly to the enhanced mortality of mice infected with HSV.

This article has been cited by other articles:

				S. P. Deshpande, M. Zheng, M. Daheshia, and B. T. Rouse Pathogenesis of Herpes Simplex Virus-Induced Ocular Immunoinflammatory Lesions in B-Cell-Deficient Mice J. Virol., April 15, 2000; 74(8): 3517 - 3524. [Abstract] [Full Text]