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The Journal of Immunology, Vol 131, Issue 3 1138-1141, Copyright © 1983 by American Association of Immunologists

ARTICLES

Accelerated 86Rb+ (K+) release from the cytotoxic T lymphocyte is a physiologic event associated with delivery of the lethal hit

JH Russell and CB Dobos

Cloned CTL have been loaded with the K+ analogue 86Rb+. When mixed with unlabeled target cells, accelerated 86Rb+ release occurs from the CTL. The magnitude of accelerated 86Rb+ release is proportional to the efficacy of the target in standard 51Cr release assays. The signal responsible for accelerated 86Rb+ release has been localized to a postbinding event and has the physiologic requirements of delivery of the lethal hit. Thus, accelerated 86Rb+ release from the CTL represents the first direct observation of a physiologic event within the CTL related to a functional CTL-target interaction.


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B. Felzen, R. Lavy, M. Garcia, G. Berke, P. Gardner, and O. Binah
Interaction of Cytotoxic T Lymphocytes and Guinea Pig Ventricular Myocytes : Pharmacological Modulation by Blocking K+ Currents in Cytotoxic T Lymphocytes
Circ. Res., February 1, 1996; 78(2): 253 - 261.
[Abstract] [Full Text]


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