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The Journal of Immunology, Vol 131, Issue 2 674-677, Copyright © 1983 by American Association of Immunologists

ARTICLES

The J744.2 cell line presents antigen in an I region restricted manner

S Schwarzbaum and B Diamond

We report here the ability of a murine macrophage-like cell line, J774.2, to present antigen to primed T cells in a genetically restricted manner. J774.2 is a subclone derived from the reticulum cell sarcoma cell line, J774. Like mature macrophages, J774.2 possesses Fc receptors for all immunoglobulin G (IgG) subclasses; it is capable of performing Fc-mediated phagocytosis, and it secretes both lysozyme and plasminogen activator.




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