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The Journal of Immunology, Vol 131, Issue 2 551-553, Copyright © 1983 by American Association of Immunologists

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Specific suppression of human T lymphocyte function by leukotriene B4

DG Payan and EJ Goetzl

Leukotriene B4, but not leukotrienes C4, D4, E4, or 12(S)-leukotriene B4, inhibited in a concentration-dependent manner the capacity of PHA- stimulated human T lymphocytes to generate LIF activity and to proliferate, as assessed by the uptake of [3H]thymidine.


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