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The Journal of Immunology, Vol 131, Issue 1 16-18, Copyright © 1983 by American Association of Immunologists

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Selective failure of accessory cell function in Moloney murine leukemia virus-tolerant mice

G Biasi, D Collavo and L Chieco-Bianchi

Accessory cell activity of spleen cells from M-MuLV neonatally injected (tolerant) mice was studied to evaluate their ability to take part in in vitro CTL generation against tumor-associated antigens induced by M- MSV. In contrast with accessory cell activity in normal spleen cells, spleen cells from M-MuLV-tolerant mice are unable to reconstitute the in vitro virus-specific CTL generation of M-MSV immune, Ia-depleted spleen cells. A selective defect seems to characterize M-MuLV-tolerant mice as their spleens constitute a good source of accessory cells for alloantigen CTL generation.


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A. Facchinetti, S. D. Santa, S. Mezzalira, A. Rosato, and G. Biasi
A Large Number of T Lymphocytes Recognize Moloney-Murine Leukemia Virus-Induced Antigens, but a Few Mediate Long-Lasting Tumor Immunosurveillance
J. Immunol., May 1, 2005; 174(9): 5398 - 5406.
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