The Journal of Immunology, Vol 130, Issue 6 2908-2914, Copyright © 1983 by American Association of Immunologists

ARTICLES

Recovery from a viral respiratory tract infection. IV. Specificity of protection by cytotoxic T lymphocytes

MA Wells, S Daniel, JY Djeu, SC Kiley and FA Ennis

Immune spleen cells enhanced for influenza-specific cytotoxic activity after exposure to virus-infected stimulator cells in vitro effect recovery when transferred to nude and immunocompetent mice with influenza pneumonia (5). This protective effect correlated with the virus-specific cytotoxic activity of the transferred lymphocytes and is removed by treatment with anti-0 serum and complement. The experiments presented here indicate that spleen cells taken directly from mice undergoing a primary or secondary infection are less protective than immune spleen cells that are restimulated in vitro before transfer. This decreased ability to clear pulmonary virus and effect survival correlated with their relatively lower levels of influenza-specific cytotoxicity. Protection did not correlate with the level of natural killer cell activity of transferred cells. The results also indicate the immune spleen cells that are protective are influenza A subtype cross-reactive and are H-2-restricted; H-2d immune spleen cells effected recovery of H-2d but not H-2k challenged mice.

This article has been cited by other articles:

				B. A. Small, S. A. Dressel, C. W. Lawrence, D. R. Drake III, M. H. Stoler, R. I. Enelow, and T. J. Braciale CD8+ T Cell-mediated Injury In Vivo Progresses in the Absence of Effector T Cells J. Exp. Med., December 17, 2001; 194(12): 1835 - 1846. [Abstract] [Full Text] [PDF]

				H. H. Nguyen, F. W. van Ginkel, H. L. Vu, M. J. Novak, J. R. McGhee, and J. Mestecky Gamma Interferon Is Not Required for Mucosal Cytotoxic T-Lymphocyte Responses or Heterosubtypic Immunity to Influenza A Virus Infection in Mice J. Virol., June 15, 2000; 74(12): 5495 - 5501. [Abstract] [Full Text]