The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Geha, R.
Right arrow Articles by Reinherz, E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Geha, R.
Right arrow Articles by Reinherz, E

The Journal of Immunology, Vol 130, Issue 6 2493-2495, Copyright © 1983 by American Association of Immunologists

COMMUNICATIONS

Identification of circulating maternal T and B lymphocytes in uncomplicated severe combined immunodeficiency by HLA typing of subpopulations of T cells separated by the fluorescence-activated cell sorter and of Epstein Barr virus-derived B cell lines

RS Geha and E Reinherz

Circulating maternal T cells were sought in a child with severe combined immunodeficiency (SCID) and no evidence of acute graft-vs-host disease, but who had small numbers (9 to 11%) of circulating T3- positive cells. HLA typing of unfractionated peripheral blood lymphocytes (PBL) and of isolated E rosette-forming cells (37 to 44% of PBL) failed to reveal the presence of maternal lymphocytes. T3-positive cells isolated by the fluorescence-activated cell sorter, however, expressed exclusively maternal HLA antigens. A lymphoblastoid B cell line established by infecting the patient's PBL with Epstein Barr virus then expressed exclusively maternal HLA antigens. The presence of maternal T and B cells in uncomplicated SCID may be more common than thought previously and calls for a careful assessment of the origin of any mature T cells that are present in affected infants. In addition, the presence of maternal cells in SCID may complicate the infant's therapy.


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
M.-C. Maurel and C. Kanellopoulos-Langevin
Heredity--Venturing Beyond Genetics
Biol Reprod, July 1, 2008; 79(1): 2 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. Vernochet, S. M. Caucheteux, M.-C. Gendron, J. Wantyghem, and C. Kanellopoulos-Langevin
Affinity-Dependent Alterations of Mouse B Cell Development by Noninherited Maternal Antigen
Biol Reprod, February 1, 2005; 72(2): 460 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
C. M. Artlett, F. W. Miller, and L. G. Rider
Persistent maternally derived peripheral microchimerism is associated with the juvenile idiopathic inflammatory myopathies
Rheumatology, November 1, 2001; 40(11): 1279 - 1284.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. M. Muller, M. Ege, A. Pottharst, A. S. Schulz, K. Schwarz, and W. Friedrich
Transplacentally acquired maternal T lymphocytes in severe combined immunodeficiency: a study of 121 patients
Blood, September 15, 2001; 98(6): 1847 - 1851.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1983 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1983 by The American Association of Immunologists, Inc. All rights reserved.