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The Journal of Immunology, Vol 130, Issue 5 2209-2213, Copyright © 1983 by American Association of Immunologists

ARTICLES

Cloned T cells with "co-helper" activity. I. Biologic activities of the clone

DD Eardley

Clones of sheep erythrocyte-(SRBC) specific helper T cells with the surface phenotype Thy-1+, Ly-1+, Ly-2- have been derived that grow in vitro in the absence of exogenous antigen or added growth factors. The IL 2-independent clone, 101.6 has been shown to produce a supernatant factor that augments the primary anti-SRBC but not anti-burro RBC responses of whole spleen cells or Ly-1 T plus B cell cultures. The supernatant does not help B cells directly. This augmenting activity is terminated "co-helper" because the enhancement requires the presence of normal Ly-1 T cells. The supernatant of 101.6 was not shown to contain IL 2; co-helper activity was distinguishable from IL 2 activity by absorption with SRBC but not with Con A blasts, and we observed that co- helper activity does not act on spleen cells that differ at the major histocompatibility complex.




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