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The Journal of Immunology, Vol 130, Issue 5 2168-2172, Copyright © 1983 by American Association of Immunologists

ARTICLES

Analytical and functional studies on the T cells of untreated and immunologically tolerant diabetes-prone BB rats

A Naji, WK Silvers, H Kimura, D Bellgrau, JF Markmann and CF Barker

Lymphocyte profiles of untreated diabetes-prone BB rats (BBDP) and their normal marrow-inoculated tolerant littermates were determined with the aid of a fluorescence-activated cell sorter by using monoclonal antibodies specific for rat T cell (W3/13) and T cell subsets (W3/25, T helper; OX8, T cytotoxic/suppressor). In contrast to non-diabetes-prone rats and to their marrow-inoculated littermates, untreated BBDP rats were found to be T lymphocytopenic with reduced W3/25+ cells and with a major loss of OX8+ cells. Moreover, their lymphocytes displayed depressed alloreactivity that was not restored by addition of exogenous IL 2.


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A. Posselt, C. Barker, A. Friedman, and A Naji
Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth
Science, May 29, 1992; 256(5061): 1321 - 1324.
[Abstract] [PDF]


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