| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 130, Issue 5 2011-2013, Copyright © 1983 by American Association of Immunologists
COMMUNICATIONS |
JL Pace, SW Russell, BA Torres, HM Johnson and PW Gray
Mouse macrophages become activated to kill tumor cells by traversing a series of steps (1-3). The first of these does not cause the expression of cytolytic activity; instead, it primes macrophages to respond to a second signal(s) that then triggers the onset of killing (4-7). The mediator that is responsible for priming is contained, along with other lymphokines, in the culture supernatants of concanavalin A-stimulated spleen cells (5-7) cloned T lymphocytes (8), or some T cell hybridomas (9). Close association has been noted between macrophage priming activity and antiviral activity that is attributable to gamma interferon (10-12). However, unequivocal evidence that the two activities are products of the same molecule has not been available. We now how conclusively by using mouse gamma interferon (MulFN-gamma)3 produced by recombinant DNA technology that, in addition to antiviral activity, this lymphokine has the capacity to induce the priming step in the process of macrophage activation for tumor cell killing.
This article has been cited by other articles:
|
|
 |
|
  H. Bashyam IFN{gamma}: Issuing macrophages a license to kill J. Exp. Med., January 22, 2007; 204(1): 3 - 3. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Vega, P. Chacon, J. Monteseirin, R. El Bekay, M. Alvarez, G. Alba, J. Conde, J. Martin-Nieto, F. J. Bedoya, E. Pintado, et al. A new role for monoamine oxidases in the modulation of macrophage-inducible nitric oxide synthase gene expression J. Leukoc. Biol., June 1, 2004; 75(6): 1093 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Segal, N. C. Lee, Y. L. Tsung, J. A. Norton, and K. Tsung The Role of IFN-{gamma} in Rejection of Established Tumors by IL-12 : Source of Production and Target Cancer Res., August 15, 2002; 62(16): 4696 - 4703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Dinges and P. M. Schlievert Role of T Cells and Gamma Interferon during Induction of Hypersensitivity to Lipopolysaccharide by Toxic Shock Syndrome Toxin 1 in Mice Infect. Immun., March 1, 2001; 69(3): 1256 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Steinmüller, G. Franke-Ullmann, M.-L. Lohmann-Matthes, and A. Emmendörffer Local Activation of Nonspecific Defense against a Respiratory Model Infection by Application of Interferon-gamma . Comparison between Rat Alveolar and Interstitial Lung Macrophages Am. J. Respir. Cell Mol. Biol., April 1, 2000; 22(4): 481 - 490. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. Winter, H.-M. Hu, W. J. Urba, and B. A. Fox Tumor Regression After Adoptive Transfer of Effector T Cells Is Independent of Perforin or Fas Ligand (APO-1L/CD95L) J. Immunol., October 15, 1999; 163(8): 4462 - 4472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Barrios-Rodiles and K. Chadee Novel Regulation of Cyclooxygenase-2 Expression and Prostaglandin E2 Production by IFN-{gamma} in Human Macrophages J. Immunol., September 1, 1998; 161(5): 2441 - 2448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Foster, B. M. Arkonac, N. E. S. Sibinga, C. Shi, M. A. Perrella, and E. Haber Regulation of CD44 Gene Expression by the Proinflammatory Cytokine Interleukin-1beta in Vascular Smooth Muscle Cells J. Biol. Chem., August 7, 1998; 273(32): 20341 - 20346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Stack, C. B. Thompson, and F. W. Fitch IL-4 Enhances Long-Term Survival of CD28-Deficient T Cells J. Immunol., March 1, 1998; 160(5): 2255 - 2262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nagoshi, P. S. Goedegebuure, U. L. Burger, N. Sadanaga, M. P. Chang, and T. J. Eberlein Successful Adoptive Cellular Immunotherapy Is Dependent on Induction of a Host Immune Response Triggered by Cytokine (IFN-{gamma} and Granulocyte/Macrophage Colony-Stimulating Factor) Producing Donor Tumor-Infiltrating Lymphocytes J. Immunol., January 1, 1998; 160(1): 334 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Jadus, C. C. Williams, M. D. Avina, M. Ly, S. Kim, Y. Liu, R. Narasaki, C. A. Lowell, and H. T. Wepsic Macrophages Kill T9 Glioma Tumor Cells Bearing the Membrane Isoform of Macrophage Colony Stimulating Factor Through a Phagocytosis-Dependent Pathway J. Immunol., January 1, 1998; 160(1): 361 - 368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hibbs Jr, R. Taintor, and Z Vavrin Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite Science, January 23, 1987; 235(4787): 473 - 476. [Abstract] [PDF]
|
|
|
|
|
|
K. Grabstein, D. Urdal, R. Tushinski, D. Mochizuki, V. Price, M. Cantrell, S Gillis, and P. Conlon Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor Science, April 25, 1986; 232(4749): 506 - 508. [Abstract] [PDF]
|
|
|
|
|
|
S Landolfo, F Cofano, M Giovarelli, M Prat, G Cavallo, and G Forni Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo Science, July 12, 1985; 229(4709): 176 - 179. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
