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The Journal of Immunology, Vol 130, Issue 4 1592-1595, Copyright © 1983 by American Association of Immunologists

ARTICLES

The ontogeny of antigen-presenting cells in fetal thymus evaluated by MLR stimulation

JH Robinson

This study demonstrates that cells with the characteristics of antigen- presenting cells (APC) are present in murine thymus from as early as 14 days gestation, around the time that T lymphopoiesis is initiated in the embryo. Thymic APC were identified as la+ adherent cells capable of presenting alloantigens to T cells in MLC. The possible role of these cells in thymocyte differentiation is discussed.




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