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The Journal of Immunology, Vol 130, Issue 3 1215-1219, Copyright © 1983 by American Association of Immunologists

ARTICLES

alpha-Interferon increases immunoglobulin production in cultured human mononuclear leukocytes

MA Rodriguez, WA Prinz, WL Sibbitt, AD Bankhurst and RC Williams Jr

Interferons (IFN) are known to modulate immune responses in either an inhibitory or a stimulating manner. The present study was initiated to investigate the mechanisms by which alpha-IFN modulates Ig production of human peripheral blood mononuclear cells (PBMC). IgG and IgM production was measured in pokeweed mitogen- (PWM) stimulated 7-day cultures of PBMC. Significant enhancement of IgM and IgG production was observed when alpha-IFN was added. Overnight preincubation followed by washing also produced significant enhancement. The effect of alpha-IFN was not obtained in the absence of PWM or T cells. The effect of alpha- IFN on cultures of B and T cells was not altered by irradiation of T cells (2000 rad). alpha-IFN was not shown to enhance the production of helper factor but did increase the responsiveness of B cells to helper factor if the B cells were preincubated with alpha-IFN. Finally, alpha- IFN did not increase the Ig production of PBMC induced by Epstein Barr virus (EBV), and the outgrowth of EBV-infected PBMC was not affected. Overall, these results show for the first time that the effect of alpha- IFN on PBMC is due to an enhanced responsiveness of B cells to helper factors produced by radioresistant T cells.


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M. Alsharifi, M. Lobigs, M. Regner, E. Lee, A. Koskinen, and A. Mullbacher
Type I Interferons Trigger Systemic, Partial Lymphocyte Activation in Response to Viral Infection
J. Immunol., October 1, 2005; 175(7): 4635 - 4640.
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