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The Journal of Immunology, Vol 130, Issue 3 1210-1214, Copyright © 1983 by American Association of Immunologists

ARTICLES

Interferon-induced enhancement of macrophage Fc receptor expression: beta-interferon treatment of C3H/HeJ macrophages results in increased numbers and density of Fc receptors

SN Vogel, DS Finbloom, KE English, DL Rosenstreich and SG Langreth

Previous studies demonstrated that the augmentation of Fc receptor- (FcR) mediated phagocytosis and binding of opsonized sheep erythrocytes is cytokine mediated. Specifically, beta-interferon- (beta-IFN) and gamma-IFN-rich preparations were shown to increase binding and phagocytosis of opsonized erythrocytes by C3H/HeJ macrophages. In this report we extend these studies by examination of the mechanisms by which highly purified beta-IFN increases FcR capacity in C3H/HeJ macrophages. Our findings indicate that beta-IFN augments FcR function for both IgG2a and IgG2b receptor subclasses. Moreover, this increased ability to bind and phagocytose opsonized erythrocytes is associated with a concomitant increase in both the number and surface membrane density of FcR.


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