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The Journal of Immunology, Vol 130, Issue 3 1129-1131, Copyright © 1983 by American Association of Immunologists

ARTICLES

Lymphocyte subpopulations in the neonate: identification of an immature subset of OKT8-positive, OKT3-negative cells

R Maccario, L Nespoli, G Mingrat, A Vitiello, AG Ugazio and GR Burgio

T cell subpopulations of lymphocytes from cord blood (CBL) of 24 newborns and from peripheral blood (a-PBL) of 24 healthy adult volunteers were assessed in T cell-enriched, T cell depleted and unseparated lymphocyte fractions by using OKT3, 4, 6, and 8 monoclonal antibodies. The results show that T cell-enriched CBL include adult numbers of OKT3+, OKT4+, OKT6+ and OKT8+ lymphocytes whereas the T cell- depleted fraction consists of a high percentage of OKT8+, OKT3-, non-E rosette-forming cells bearing a PNA receptor. The presence of the PNA receptor and the lack of the OKT3+ antigen strongly support the hypothesis that the subset of OKT8+ cells in cord blood includes immature T lymphocytes that may represent an intermediate stage between thymocytes and mature peripheral T cells.


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Z. Szepfalusi
The Maturation of the Fetal and Neonatal Immune System
J. Nutr., September 1, 2008; 138(9): 1773S - 1781S.
[Abstract] [Full Text] [PDF]


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