The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aalberse, R. C.
Right arrow Articles by van Leeuwen, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aalberse, R. C.
Right arrow Articles by van Leeuwen, J.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Immunization

The Journal of Immunology, Vol 130, Issue 2 722-726, Copyright © 1983 by American Association of Immunologists

ARTICLES

Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response

RC Aalberse, R van der Gaag and J van Leeuwen

Labeled antigen-binding tests were used to determine quantitatively the contribution of IgG4 antibodies to the total IgG antibody response in humans. In agreement with literature, we found no IgG4-restricted antibody responses with tetanus toxoid or streptococcal carbohydrate. In the serum of individuals immunized for several years with phospholipase (PLA) from honey bee venom, grass pollen allergen, or house dust mite allergen, we often found that more than 50% of the total antigen-binding capacity was due to IgG4 antibodies. In the case of beekeepers, it could clearly be shown that during prolonged immunization a shift in the IgG4:IgG1 antibody ratio occurs that finally results in an IgG4-dominated antibody response. Evidence is provided that antigen-binding assays may even underestimate the contribution of IgG4 antibodies, because in contrast to IgG1 antibodies, IgG4 antibodies act as monovalent antibodies in being unable to cross-link immunosorbent-bound antigen and radiolabeled antigen.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
T. Rispens, P. Ooievaar-De Heer, E. Vermeulen, J. Schuurman, M. van der Neut Kolfschoten, and R. C. Aalberse
Human IgG4 Binds to IgG4 and Conformationally Altered IgG1 via Fc-Fc Interactions
J. Immunol., April 1, 2009; 182(7): 4275 - 4281.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
W H Bos, G M Bartelds, M Vis, A R van der Horst, G J Wolbink, R J van de Stadt, D van Schaardenburg, B A C Dijkmans, W F Lems, M T Nurmohamed, et al.
Preferential decrease in IgG4 anti-citrullinated protein antibodies during treatment with tumour necrosis factor blocking agents in patients with rheumatoid arthritis
Ann Rheum Dis, April 1, 2009; 68(4): 558 - 563.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. L. Sinquett, R. L. Dryer, V. Marcelli, A. Batheja, and L. R. Covey
Single Nucleotide Changes in the Human I{gamma}1 and I{gamma}4 Promoters Underlie Different Transcriptional Responses to CD40
J. Immunol., February 15, 2009; 182(4): 2185 - 2193.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
I. Nebie, A. Diarra, A. Ouedraogo, I. Soulama, E. C. Bougouma, A. B. Tiono, A. T. Konate, R. Chilengi, M. Theisen, D. Dodoo, et al.
Humoral Responses to Plasmodium falciparum Blood-Stage Antigens and Association with Incidence of Clinical Malaria in Children Living in an Area of Seasonal Malaria Transmission in Burkina Faso, West Africa
Infect. Immun., February 1, 2008; 76(2): 759 - 766.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Pilette, K. T. Nouri-Aria, M. R. Jacobson, L. K. Wilcock, B. Detry, S. M. Walker, J. N. Francis, and S. R. Durham
Grass Pollen Immunotherapy Induces an Allergen-Specific IgA2 Antibody Response Associated with Mucosal TGF-beta Expression
J. Immunol., April 1, 2007; 178(7): 4658 - 4666.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Nagato, H. Kobayashi, M. Yanai, K. Sato, N. Aoki, K. Oikawa, S. Kimura, Y. Abe, E. Celis, Y. Harabuchi, et al.
Functional Analysis of Birch Pollen Allergen Bet v 1-Specific Regulatory T Cells
J. Immunol., January 15, 2007; 178(2): 1189 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
C. Wongkham, C. Tantrawatpan, P. M. Intapan, W. Maleewong, S. Wongkham, and K. Nakashima
Evaluation of Immunoglobulin G Subclass Antibodies against Recombinant Fasciola gigantica Cathepsin L1 in an Enzyme-Linked Immunosorbent Assay for Serodiagnosis of Human Fasciolosis
Clin. Vaccine Immunol., October 1, 2005; 12(10): 1152 - 1156.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. J. Reefer, R. M. Carneiro, N. J. Custis, T. A. E. Platts-Mills, S.-S. J. Sung, J. Hammer, and J. A. Woodfolk
A Role for IL-10-Mediated HLA-DR7-Restricted T Cell-Dependent Events in Development of the Modified Th2 Response to Cat Allergen
J. Immunol., March 1, 2004; 172(5): 2763 - 2772.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. T. Nouri-Aria, P. A. Wachholz, J. N. Francis, M. R. Jacobson, S. M. Walker, L. K. Wilcock, S. Q. Staple, R. C. Aalberse, S. J. Till, and S. R. Durham
Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity
J. Immunol., March 1, 2004; 172(5): 3252 - 3259.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. Cabrera, C. Yone, A. E. Tebo, J. van Aaken, B. Lell, P. G. Kremsner, and A. J. F. Luty
Immunoglobulin G Isotype Responses to Variant Surface Antigens of Plasmodium falciparum in Healthy Gabonese Adults and Children during and after Successive Malaria Attacks
Infect. Immun., January 1, 2004; 72(1): 284 - 294.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Sehra, G. Pynaert, K. Tournoy, A. Haegeman, P. Matthys, Y. Tagawa, R. Pauwels, and J. Grooten
Airway IgG Counteracts Specific and Bystander Allergen-Triggered Pulmonary Inflammation by a Mechanism Dependent on Fc{gamma}R and IFN-{gamma}
J. Immunol., August 15, 2003; 171(4): 2080 - 2089.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. G. Tangye, A. Ferguson, D. T. Avery, C. S. Ma, and P. D. Hodgkin
Isotype Switching by Human B Cells Is Division-Associated and Regulated by Cytokines
J. Immunol., October 15, 2002; 169(8): 4298 - 4306.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
T. Bhattacharyya, A. Santra, D. N. G. Majumder, and B. P. Chatterjee
Possible Approach for Serodiagnosis of Ascariasis by Evaluation of Immunoglobulin G4 Response Using Ascaris lumbricoides Somatic Antigen
J. Clin. Microbiol., August 1, 2001; 39(8): 2991 - 2994.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Zang, A. K. Atmadja, P. Gray, J. E. Allen, C. A. Gray, R. A. Lawrence, M. Yazdanbakhsh, and R. M. Maizels
The Serpin Secreted by Brugia malayi Microfilariae, Bm-SPN-2, Elicits Strong, but Short-Lived, Immune Responses in Mice and Humans
J. Immunol., November 1, 2000; 165(9): 5161 - 5169.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. VERCELLI
One Cytokine, Two Isotypes . A Trojan Horse, Pandora's Box, and an Evolving Paradigm
Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): S86 - 90.
[Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. M. O'Brien-Simpson, C. L. Black, P. S. Bhogal, S. M. Cleal, N. Slakeski, T. J. Higgins, and E. C. Reynolds
Serum Immunoglobulin G (IgG) and IgG Subclass Responses to the RgpA-Kgp Proteinase-Adhesin Complex of Porphyromonas gingivalis in Adult Periodontitis
Infect. Immun., May 1, 2000; 68(5): 2704 - 2712.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
T. BALL, T. FUCHS, W. R. SPERR, P. VALENT, L. VANGELISTA, D. KRAFT, and R. VALENTA
B cell epitopes of the major timothy grass pollen allergen, Phl p 1, revealed by gene fragmentation as candidates for immunotherapy
FASEB J, August 1, 1999; 13(11): 1277 - 1290.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
C. A. AKDIS and K. BLASER
IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy
FASEB J, April 1, 1999; 13(6): 603 - 609.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
Q. Pan, H. Rabbani, and L. Hammarstrom
Characterization of Human {gamma}4 Switch Region Polymorphisms Suggests a Meiotic Recombinational Hot Spot Within the Ig Locus: Influence of S Region Length on IgG4 Production
J. Immunol., October 1, 1998; 161(7): 3520 - 3526.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Vrtala, T. Ball, S. Spitzauer, B. Pandjaitan, C. Suphioglu, B. Knox, W. R. Sperr, P. Valent, D. Kraft, and R. Valenta
Immunization with Purified Natural and Recombinant Allergens Induces Mouse IgG1 Antibodies That Recognize Similar Epitopes as Human IgE and Inhibit the Human IgE-Allergen Interaction and Allergen-Induced Basophil Degranulation
J. Immunol., June 15, 1998; 160(12): 6137 - 6144.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J.-I. Choi, R. E. Schifferle, F. Yoshimura, and B.-W. Kim
Capsular Polysaccharide-Fimbrial Protein Conjugate Vaccine Protects against Porphyromonas gingivalis Infection in SCID Mice Reconstituted with Human Peripheral Blood Lymphocytes
Infect. Immun., January 1, 1998; 66(1): 391 - 393.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
M. Hakoda, N. Kamatani, A. Taniguchi, H. Ueda, H. Yamanaka, C. Terai, and S. Kashiwazaki
Generation and molecular characterisation of monoclonal IgG4 rheumatoid factor from a patient with rheumatoid arthritis
Ann Rheum Dis, January 1, 1997; 56(1): 74 - 77.
[Abstract] [Full Text]

Home page
 CROBMHome page
J. L. Ebersole
Systemic Humoral Immune Responses in Periodontal Disease
Critical Reviews in Oral Biology & Medicine, January 1, 1990; 1(4): 283 - 331.
[Full Text] [PDF]

Home page
 JAMAHome page
P. S. Creticos and P. S. Norman
Immunotherapy With Allergens
JAMA, November 27, 1987; 258(20): 2874 - 2880.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1983 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1983 by The American Association of Immunologists, Inc. All rights reserved.