The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Breit, S. N.
Right arrow Articles by Penny, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Breit, S. N.
Right arrow Articles by Penny, R.

The Journal of Immunology, Vol 130, Issue 2 681-686, Copyright © 1983 by American Association of Immunologists

ARTICLES

The effect of alpha 1 antitrypsin on the proliferative response of human peripheral blood lymphocytes

SN Breit, E Luckhurst and R Penny

In evaluating immune aberrations in patients with alpha 1 antitrypsin (alpha 1 AT) deficiency, we have previously shown that they exhibit enhanced lymphocyte responsiveness to PHA that is serum mediated. In this study, we demonstrate suppression of the PHA response by using purified alpha 1 AT, and also similar but less marked suppression of the Con A response. alpha 1 AT, however, has no effect whatsoever on PWM-induced proliferation. This effect is demonstrable provided alpha 1 AT is added within 4 hr of mitogen activation and is mediated by its action on adherent cells rather than on proliferating lymphocytes. Adherent cells still exhibit this effect if pulsed with alpha 1 AT, then thoroughly washed before their activation. This suggests that it may be inhibiting a membrane serine esterase already activated before the addition of PHA. Thus alpha 1 AT may modulate the activation of T cells through its effect on monocytes, leading to abnormalities in immunoregulation, and hence a predisposition to the development of a variety of immunologic disorders in alpha 1 AT-deficient subjects.


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Koulmanda, M. Bhasin, L. Hoffman, Z. Fan, A. Qipo, H. Shi, S. Bonner-Weir, P. Putheti, N. Degauque, T. A. Libermann, et al.
Curative and {beta} cell regenerative effects of {alpha}1-antitrypsin treatment in autoimmune diabetic NOD mice
PNAS, October 21, 2008; 105(42): 16242 - 16247.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. Takubo, A. Guerassimov, H. Ghezzo, A. Triantafillopoulos, J. H. T. Bates, J. R. Hoidal, and M. G. Cosio
{alpha}1-Antitrypsin Determines the Pattern of Emphysema and Function in Tobacco Smoke-exposed Mice: Parallels with Human Disease
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1596 - 1603.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Zang, A. K. Atmadja, P. Gray, J. E. Allen, C. A. Gray, R. A. Lawrence, M. Yazdanbakhsh, and R. M. Maizels
The Serpin Secreted by Brugia malayi Microfilariae, Bm-SPN-2, Elicits Strong, but Short-Lived, Immune Responses in Mice and Humans
J. Immunol., November 1, 2000; 165(9): 5161 - 5169.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1983 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1983 by The American Association of Immunologists, Inc. All rights reserved.