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The Journal of Immunology, Vol 130, Issue 1 162-164, Copyright © 1983 by American Association of Immunologists

ARTICLES

Two different rheumatoid factor-producing cell populations distinguished by the mouse erythrocyte receptor and responsiveness to polyclonal B cell activators

S Fong, JH Vaughan and DA Carson

The subsets of human peripheral blood B lymphocytes from which Epstein Barr virus- (EBV) and pokeweed mitogen- (PWM) induced IgM anti-IgG autoantibody-producing B cells arise have been compared. EBV-induced IgM anti-IgG autoantibodies preferentially derive from a subset of B cells that forms rosettes with mouse erythrocytes. In contrast, PWM- induced IgM anti-IgG antibodies preferentially arise from a B cell subset lacking the mouse erythrocyte receptor.


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R. Hardy, K Hayakawa, M Shimizu, K Yamasaki, and T Kishimoto
Rheumatoid factor secretion from human Leu-1+ B cells
Science, April 3, 1987; 236(4797): 81 - 83.
[Abstract] [PDF]


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