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The Journal of Immunology, Vol 129, Issue 6 2486-2489, Copyright © 1982 by American Association of Immunologists

ARTICLES

B cell growth factor and T cell growth factor produced by mitogen- stimulated normal human peripheral blood T lymphocytes are distinct molecules

A Muraguchi, T Kasahara, JJ Oppenheim and AS Fauci

Using a recently described assay for inducing and measuring the proliferation of normal human B cells in the absence of differentiation, we have demonstrated that B cell growth factor (BCGF) activity can be obtained from the culture of human peripheral blood mononuclear cells in the presence of mitogens. Using Sephacryl S-200 gel filtration, BCGF activity was demonstrated in the 20 to 30K m.w. fractions of mitogen-stimulated peripheral blood mononuclear cells. However, this fraction also showed substantial T cell growth factor (TCGF) activity. Despite this overlapping of m.w., BCGF activity could clearly be separated from TCGF activity by selective absorption of factor-containing supernatants with the interleukin 2 activity by using interleukin 2-dependent cells without any diminution of BCGF activity, strongly suggesting that these two factors may be distinct molecular entities.


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J. Kehrl, M Alvarez-Mon, G. Delsing, and A. Fauci
Lymphotoxin is an important T cell-derived growth factor for human B cells
Science, November 20, 1987; 238(4830): 1144 - 1146.
[Abstract] [PDF]


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