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The Journal of Immunology, Vol 128, Issue 6 2652-2655, Copyright © 1982 by American Association of Immunologists

ARTICLES

Induction of B cell differentiation in vitro by bursal epithelium

E Eerola, O Lassila, DG Gilmour and A Toivanen

The inductive capacity of in vitro cultured epithelium of chicken bursa of Fabricius and of its soluble products on B cells precursors was evaluated. The appearance of surface Ia-like antigens was used as an indicator of the early B cell differentiation in vitro. Cultured bursal epithelium as well as soluble substances produced by it were able to initiate B cell development; Ia alloantigens were induced by both syngeneic and allogeneic epithelia. In both cases the induced Ia antigens represented the genotype of the responding cells.




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