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The Journal of Immunology, Vol 128, Issue 4 1502-1506, Copyright © 1982 by American Association of Immunologists

ARTICLES

Immune responses in vitro. XII. Two independently segregating loci control Mis product(s)

RE Click, MM Azar and VE Anderson

Distribution analyses of Misa in (BALB/c x DBA/2)F2 animals indicate that two independently segregating loci control the expression of Misa products. The results were dependent upon the use of x-irradiated cells a the antigen in MLR. The use of non-x-irradiated antigen in the MLR led to results that were uninterpretable because both DBA/2 and (BALB/c x DBA/2)F1 cells responded to x-irradiated BALB/c cells. Even though DBA/2 cells did not respond to (BALB/c x DBA/2)F1 cells, their reactivity to BALB/c cells indicates that the Misb of BALB/c is not null.




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