The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tenovuo, J.
Right arrow Articles by Rahemtulla, B. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tenovuo, J.
Right arrow Articles by Rahemtulla, B. M.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*HYDROGEN PEROXIDE

The Journal of Immunology, Vol 128, Issue 2 726-731, Copyright © 1982 by American Association of Immunologists

ARTICLES

Interaction of specific and innate factors of immunity: IgA enhances the antimicrobial effect of the lactoperoxidase system against Streptococcus mutans

J Tenovuo, Z Moldoveanu, J Mestecky, KM Pruitt and BM Rahemtulla

The antimicrobial effect of the lactoperoxidase (LPO) system (enzyme with the thiocyanate ion and hydrogen peroxide) on Streptococcus mutans NCTC 10449 (serotype c) was significantly enhanced when the system was combined with secretory IgA. Similar enhancement was observed with LPO- myeloma IgA1 or IgA2 combinations. This enhancement of the antimicrobial efficiency was not dependent on the presence of specific antibodies to S. mutans in the IgA preparation, but seemed to require binding between LPO and immunoglobulin. However, neither human polyclonal nor myeloma IgG or IgM nor rabbit IgG enhanced the antibacterial activity of the LPO system. None of the immunoglobulins, when added alone, produced antimicrobial effects. LPO was shown to bind to colostral secretory IgA, myeloma IgA1, IgA2, and to a lesser degree to monoclonal and polyclonal IgG and monoclonal IgM. This binding had a stabilizing effect on the enzyme activity. Our results suggest that IgA significantly enhances the antibacterial efficiency of one of the innate immune factors--the LPO system.


This article has been cited by other articles:


Home page
 JDRHome page
J. Tenovuo
Antimicrobial Agents in Saliva--Protection for the Whole Body
Journal of Dental Research, December 1, 2002; 81(12): 807 - 809.
[Full Text] [PDF]

Home page
 ADRHome page
M. Lenander-Lumikari and V. Loimaranta
Saliva and Dental Caries
Advances in Dental Research, December 1, 2000; 14(1): 40 - 47.
[Abstract] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. J. Ratner and A. Prince
Lactoperoxidase . New Recognition of an "Old" Enzyme in Airway Defenses
Am. J. Respir. Cell Mol. Biol., June 1, 2000; 22(6): 642 - 644.
[Full Text]

Home page
 J. Nutr.Home page
T. Oho, Y. Shimazaki, M. Mitoma, M. Yoshimura, Y. Yamashita, K. Okano, Y. Nakano, H. Kawagoe, M. Fukuyama, N. Fujihara, et al.
Bovine Milk Antibodies against Cell Surface Protein Antigen PAc-Glucosyltransferase Fusion Protein Suppress Cell Adhesion and Alter Glucan Synthesis of Streptococcus mutans
J. Nutr., October 1, 1999; 129(10): 1836 - 1841.
[Abstract] [Full Text]

Home page
 JDRHome page
J.D. Rudney, K.L. Hickey, and Z. Ji
Cumulative Correlations of Lysozyme, Lactoferrin, Peroxidase, S-IgA, Amylase, and Total Protein Concentrations with Adherence of Oral Viridans Streptococci to Microplates Coated with Human Saliva
Journal of Dental Research, March 1, 1999; 78(3): 759 - 768.
[Abstract] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
V. Loimaranta, J. Tenovuo, L. Koivisto, and M. Karp
Generation of Bioluminescent Streptococcus mutans and Its Usage in Rapid Analysis of the Efficacy of Antimicrobial Compounds
Antimicrob. Agents Chemother., August 1, 1998; 42(8): 1906 - 1910.
[Abstract] [Full Text]

Home page
 Microbiol. Mol. Biol. Rev.Home page
H. Marcotte and M. C. Lavoie
Oral Microbial Ecology and the Role of Salivary Immunoglobulin A
Microbiol. Mol. Biol. Rev., March 1, 1998; 62(1): 71 - 109.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
V. Kirstila, P. Hakkinen, H. Jentsch, P. Vilja, and J. Tenovuo
Longitudinal Analysis of the Association of Human Salivary Antimicrobial Agents with Caries Increment and Cariogenic Micro-organisms: A Two-year Cohort Study
Journal of Dental Research, January 1, 1998; 77(1): 73 - 80.
[Abstract] [PDF]

Home page
 CROBMHome page
J.D. Rudney
Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?
Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(4): 343 - 367.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
M. Lenander-Lumikari, B. Mansson-Rahemtulla, and F. Rahemtulla
Lysozyme Enhances the Inhibitory Effects of the Peroxidase System on Glucose Metabolism of Streptococcus mutans
Journal of Dental Research, March 1, 1992; 71(3): 484 - 490.
[Abstract] [PDF]

Home page
 CROBMHome page
S. M. Michalek and N. K. Childers
Development and Outlook for a Caries Vaccine
Critical Reviews in Oral Biology & Medicine, January 1, 1990; 1(1): 37 - 54.
[Full Text] [PDF]

Home page
 JDRHome page
I.D. Mandel, J. Behrman, R. Levy, and D. Weinstein
The Salivary Lactoperoxidase System in Caries-resistant and -susceptible Adults
Journal of Dental Research, August 1, 1983; 62(8): 922 - 925.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1982 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1982 by The American Association of Immunologists, Inc. All rights reserved.