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The Journal of Immunology, Vol 126, Issue 3 851-855, Copyright © 1981 by American Association of Immunologists
ARTICLES |
JA Hamilton and J Slywka
Conditioned medium from concanavalin A-stimulated human peripheral blood mononuclear cells (c-MCCM) stimulates the plasminogen activator (PA) production of nonrheumatoid human synovial fibroblasts obtained from explant cultures. The effect of this synovial fibroblast- stimulating activity is observed within 2 to 4 hr and requires RNA and protein synthesis. Reversible morphological changes in the synovial cells can be observed as a result of c-MCCM action. These enzymatic and morphologic changes are similar to some of the effects of transforming viruses and tumor promoters on target cells. The possible significance of these data for an understanding of the cellular interactions involved in the formation and function of the rheumatoid "pannus" is discussed.
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  A. D. Cook, E. L. Braine, I. K. Campbell, and J. A. Hamilton Differing Roles for Urokinase and Tissue-Type Plasminogen Activator in Collagen-Induced Arthritis Am. J. Pathol., March 1, 2002; 160(3): 917 - 926. [Abstract] [Full Text] [PDF]
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 Y. H. Yang, P. Carmeliet, and J. A. Hamilton Tissue-Type Plasminogen Activator Deficiency Exacerbates Arthritis J. Immunol., July 15, 2001; 167(2): 1047 - 1052. [Abstract] [Full Text] [PDF]
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 R. Davies, D. Rifkin, R Tepper, A Miller, and R Kucherlapati A polypeptide secreted by transformed cells that modulates human plasminogen activator production Science, July 8, 1983; 221(4606): 171 - 173. [Abstract] [PDF]
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