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The Journal of Immunology, Vol 125, Issue 6 2665-2672, Copyright © 1980 by American Association of Immunologists

ARTICLES

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement

M Sarmiento, AL Glasebrook and FW Fitch

Five rat monoclonal antibodies have been derived that express specificities for determinants present on the molecular complex bearing the Lyt 2 antigen. SDS-polyacrylamide gel electrophoresis of 125I- labeled polypeptides precipitated by each of these antibodies reveal 3 components (150,000, 75,000, and 33,000 daltons), and 2 components (44,000 and 33,000 daltons) when analyzed under nonreducing and reducing conditions, respectively. Two of these antibodies are IgG and are specific for the Lyt 2.2 determinant; the other 3 are IgM and react with determinants other than Lyt 2.2, which are nonpolymorphic. Each of the 5 antibodies can block the cytolytic activities of 5-day MLC cells or of cloned cytolytic T cells in the absence of C. Treatment of responding spleen cells with any of these antibodies and C inhibits the generation of cytolytic activity in MLC.


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Prophylactic DNA vaccine for hepatitis C virus (HCV) infection: HCV-specific cytotoxic T lymphocyte induction and protection from HCV-recombinant vaccinia infection in an HLA-A2.1 transgenic mouse model
PNAS, January 4, 2000; 97(1): 297 - 302.
[Abstract] [Full Text] [PDF]

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 Int ImmunolHome page
S. L. Epstein, A. Stack, J. A. Misplon, C.-Y. Lo, H. Mostowski, J. Bennink, and K. Subbarao
Vaccination with DNA encoding internal proteins of influenza virus does not require CD8+ cytotoxic T lymphocytes: either CD4+ or CD8+ T cells can promote survival and recovery after challenge
Int. Immunol., January 1, 2000; 12(1): 91 - 101.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
Y.-G. Lai, V. Gelfanov, V. Gelfanova, L. Kulik, C.-L. Chu, S.-W. Jeng, and N.-S. Liao
IL-15 Promotes Survival But Not Effector Function Differentiation of CD8+ TCR{alpha}{beta}+ Intestinal Intraepithelial Lymphocytes
J. Immunol., December 1, 1999; 163(11): 5843 - 5850.
[Abstract] [Full Text] [PDF]

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 JEMHome page
R. Bosselut, W. Zhang, J. M. Ashe, J. L. Kopacz, L. E. Samelson, and A. Singer
Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction
J. Exp. Med., November 15, 1999; 190(10): 1517 - 1526.
[Abstract] [Full Text] [PDF]

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 Infect. Immun.Home page
Y. Charoenvit, V. F. Majam, G. Corradin, J. B. Sacci Jr., R. Wang, D. L. Doolan, T. R. Jones, E. Abot, M. E. Patarroyo, F. Guzman, et al.
CD4+ T-Cell- and Gamma Interferon-Dependent Protection against Murine Malaria by Immunization with Linear Synthetic Peptides from a Plasmodium yoelii 17-Kilodalton Hepatocyte Erythrocyte Protein
Infect. Immun., November 1, 1999; 67(11): 5604 - 5614.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
Y.-T. Chen, F.-L. Chen, and J. T. Kung
Age-Associated Rapid and Stat6-Independent IL-4 Production by NK1-CD4+8- Thymus T Lymphocytes
J. Immunol., November 1, 1999; 163(9): 4747 - 4753.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
E. Flano, D. L. Woodland, and M. A. Blackman
Requirement for CD4+ T Cells in V{beta}4+CD8+ T Cell Activation Associated with Latent Murine Gammaherpesvirus Infection
J. Immunol., September 15, 1999; 163(6): 3403 - 3408.
[Abstract] [Full Text] [PDF]

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 Infect. Immun.Home page
A. Kariyone, K. Higuchi, S. Yamamoto, A. Nagasaka-Kametaka, M. Harada, A. Takahashi, N. Harada, K. Ogasawara, and K. Takatsu
Identification of Amino Acid Residues of the T-Cell Epitope of Mycobacterium tuberculosis alpha Antigen Critical for Vbeta 11+ Th1 Cells
Infect. Immun., September 1, 1999; 67(9): 4312 - 4319.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Cell Mol. Bio.Home page
K. Haneda, K. Sano, G. Tamura, H. Shirota, Y. Ohkawara, T. Sato, S. Habu, and K. Shirato
Transforming Growth Factor-beta Secreted from CD4+ T Cells Ameliorates Antigen-Induced Eosinophilic Inflammation . A Novel High-Dose Tolerance in the Trachea
Am. J. Respir. Cell Mol. Biol., August 1, 1999; 21(2): 268 - 274.
[Abstract] [Full Text]

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 J. Immunol.Home page
A. Wack, P. Corbella, N. Harker, K. Roderick, T. Norton, K. Williams, O. Williams, and D. Kioussis
Th Cells and Th2 Responses Can Develop in the Absence of MHC Class II-CD4 Interactions
J. Immunol., August 1, 1999; 163(3): 1162 - 1169.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. A. Coppola, E. Flano, P. Nguyen, C. L. Hardy, R. D. Cardin, N. Shastri, D. L. Woodland, and M. A. Blackman
Apparent MHC-Independent Stimulation of CD8+ T Cells In Vivo During Latent Murine Gammaherpesvirus Infection
J. Immunol., August 1, 1999; 163(3): 1481 - 1489.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
Z.-Q. Wu, Q. Vos, Y. Shen, A. Lees, S. R. Wilson, D. E. Briles, W. C. Gause, J. J. Mond, and C. M. Snapper
In Vivo Polysaccharide-Specific IgG Isotype Responses to Intact Streptococcus pneumoniae Are T Cell Dependent and Require CD40- and B7-Ligand Interactions
J. Immunol., July 15, 1999; 163(2): 659 - 667.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
J. M. McNally, D. Dempsey, R. M. Wolcott, R. Chervenak, and S. R. Jennings
Phenotypic Identification of Antigen-Dependent and Antigen-Independent CD8 CTL Precursors in the Draining Lymph Node During Acute Cutaneous Herpes Simplex Virus Type 1 Infection
J. Immunol., July 15, 1999; 163(2): 675 - 681.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
L. Liu, E. Flano, E. J. Usherwood, S. Surman, M. A. Blackman, and D. L. Woodland
Lytic Cycle T Cell Epitopes Are Expressed in Two Distinct Phases During MHV-68 Infection
J. Immunol., July 15, 1999; 163(2): 868 - 874.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
D. L. Doolan and S. L. Hoffman
IL-12 and NK Cells Are Required for Antigen-Specific Adaptive Immunity Against Malaria Initiated by CD8+ T Cells in the Plasmodium yoelii Model
J. Immunol., July 15, 1999; 163(2): 884 - 892.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
D. Jankovic, M. C. Kullberg, N. Noben-Trauth, P. Caspar, J. M. Ward, A. W. Cheever, W. E. Paul, and A. Sher
Schistosome-Infected IL-4 Receptor Knockout (KO) Mice, in Contrast to IL-4 KO Mice, Fail to Develop Granulomatous Pathology While Maintaining the Same Lymphokine Expression Profile
J. Immunol., July 1, 1999; 163(1): 337 - 342.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Cell Mol. Bio.Home page
K. Sano, K. Haneda, G. Tamura, and K. Shirato
Ovalbumin (OVA) and Mycobacterium tuberculosis Bacilli Cooperatively Polarize Anti-OVA T-helper (Th) Cells toward a Th1-Dominant Phenotype and Ameliorate Murine Tracheal Eosinophilia
Am. J. Respir. Cell Mol. Biol., June 1, 1999; 20(6): 1260 - 1267.
[Abstract] [Full Text]

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 Am. J. Pathol.Home page
C. A. Yiamouyiannis, C. M. Schramm, L. Puddington, P. Stengel, E. Baradaran-Hosseini, W. W. Wolyniec, H. E. Whiteley, and R. S. Thrall
Shifts in Lung Lymphocyte Profiles Correlate with the Sequential Development of Acute Allergic and Chronic Tolerant Stages in a Murine Asthma Model
Am. J. Pathol., June 1, 1999; 154(6): 1911 - 1921.
[Abstract] [Full Text] [PDF]

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 JEMHome page
L. Lefrancois, C. M. Parker, S. Olson, W. Muller, N. Wagner, and L. Puddington
The Role of {beta}7 Integrins in CD8 T Cell Trafficking During an Antiviral Immune Response
J. Exp. Med., May 17, 1999; 189(10): 1631 - 1638.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
R. Khattri, J. A. Auger, M. D. Griffin, A. H. Sharpe, and J. A. Bluestone
Lymphoproliferative Disorder in CTLA-4 Knockout Mice Is Characterized by CD28-Regulated Activation of Th2 Responses
J. Immunol., May 15, 1999; 162(10): 5784 - 5791.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. C. Brunner, C. A. Chambers, F. K.-M. Chan, J. Hanke, A. Winoto, and J. P. Allison
CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation
J. Immunol., May 15, 1999; 162(10): 5813 - 5820.
[Abstract] [Full Text] [PDF]

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 J. Virol.Home page
A. I. Ramsingh, W. T. Lee, D. N. Collins, and L. E. Armstrong
T Cells Contribute to Disease Severity during Coxsackievirus B4 Infection
J. Virol., April 1, 1999; 73(4): 3080 - 3086.
[Abstract] [Full Text]

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 J. Immunol.Home page
M. Bonnard, L. Haughn, and M. Julius
CD4-Mediated Inhibiton of IL-2 Production in Activated T Cells
J. Immunol., February 1, 1999; 162(3): 1252 - 1260.
[Abstract] [Full Text] [PDF]

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 JEMHome page
L. Girgis, M. M. Davis, and B. F. de St. Groth
The Avidity Spectrum of T Cell Receptor Interactions Accounts for T Cell Anergy in a Double Transgenic Model
J. Exp. Med., January 18, 1999; 189(2): 265 - 278.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
D. W. White, A. MacNeil, D. H. Busch, I. M. Pilip, E. G. Pamer, and J. T. Harty
Perforin-Deficient CD8+ T Cells: In Vivo Priming and Antigen-Specific Immunity Against Listeria monocytogenes
J. Immunol., January 15, 1999; 162(2): 980 - 988.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. Shirai, T. Arichi, M. Chen, M. Nishioka, K. Ikeda, H. Takahashi, N. Enomoto, T. Saito, M. E. Major, T. Nakazawa, et al.
T Cell Recognition of Hypervariable Region-1 from Hepatitis C Virus Envelope Protein with Multiple Class II MHC Molecules in Mice and Humans: Preferential Help for Induction of Antibodies to the Hypervariable Region
J. Immunol., January 1, 1999; 162(1): 568 - 576.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
R. S. Lin, C. Rodriguez, A. Veillette, and H. F. Lodish
Zinc Is Essential for Binding of p56lck to CD4 and CD8alpha
J. Biol. Chem., December 4, 1998; 273(49): 32878 - 32882.
[Abstract] [Full Text] [PDF]

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 JEMHome page
L. K. Selin, S. M. Varga, I. C. Wong, and R. M. Welsh
Protective Heterologous Antiviral Immunity and Enhanced Immunopathogenesis Mediated by Memory T Cell Populations
J. Exp. Med., November 2, 1998; 188(9): 1705 - 1715.
[Abstract] [Full Text] [PDF]

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 Infect. Immun.Home page
B. Wizel, N. Garg, and R. L. Tarleton
Vaccination with Trypomastigote Surface Antigen 1-Encoding Plasmid DNA Confers Protection against Lethal Trypanosoma cruzi Infection
Infect. Immun., November 1, 1998; 66(11): 5073 - 5081.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
W. T. Lee, V. Shiledar-Baxi, G. M. Winslow, D. Mix, and D. B. Murphy
Self-Restricted Dual Receptor Memory T Cells
J. Immunol., November 1, 1998; 161(9): 4513 - 4519.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
A. Shustov, P. Nguyen, F. Finkelman, K. B. Elkon, and C. S. Via
Differential Expression of Fas and Fas Ligand in Acute and Chronic Graft-Versus-Host Disease: Up-Regulation of Fas and Fas Ligand Requires CD8+ T Cell Activation and IFN-{gamma} Production
J. Immunol., September 15, 1998; 161(6): 2848 - 2855.
[Abstract] [Full Text] [PDF]


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