The Journal of Immunology, Vol 125, Issue 3 1104-1108, Copyright © 1980 by American Association of Immunologists

ARTICLES

Relative susceptibilities of T cell subsets involved in delayed-type hypersensitivity to sheep red blood cells to the in vitro action of 4- hydroperoxycyclophosphamide

SH Kaufmann, H Hahn and T Diamantstein

4-Hydroperoxycyclophosphamide, a derivative of cyclophosphamide, in aqueous solution yields 4-hydroxycyclophosphamide, which acts on lymphocytes in vitro. This compound was employed to determine the relative susceptibilities of T cell subsets involved in delayed-type hypersensitivity to sheep red blood cells in vitro. The following ranking order could be established: precursors of suppressor T cells > antigen-activated suppressor T cells > T cells mediating DTH. These data provide direct in vitro evidence that the enhancement of the cellular immune response to sheep red blood cells by cyclophosphamide is due to selective inactivation of suppressor T cells or their precursors, respectively.

This article has been cited by other articles:

				C. Karnbach, M. R. Daws, E. C. Niemi, and M. C. Nakamura Immune Rejection of a Large Sarcoma Following Cyclophosphamide and IL-12 Treatment Requires Both NK and NK T Cells and Is Associated with the Induction of a Novel NK T Cell Population J. Immunol., September 1, 2001; 167(5): 2569 - 2576. [Abstract] [Full Text] [PDF]

				K. Tsung, J. B. Meko, Y. L. Tsung, G. R. Peplinski, and J. A. Norton Immune Response Against Large Tumors Eradicated by Treatment with Cyclophosphamide and IL-12 J. Immunol., February 1, 1998; 160(3): 1369 - 1377. [Abstract] [Full Text] [PDF]