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The Journal of Immunology, Vol 125, Issue 1 293-299, Copyright © 1980 by American Association of Immunologists

ARTICLES

Two populations of Ia-like molecules on a human B cell line

LA Lampson and R Levy

Evidence is presented for two populations of Ia-like molecules on the human B cell line Raji. Two monoclonal antibodies, L203 and L227, are described. Both recognize nonpolymorphic determinants on B cell antigens. Both immunoprecipitate 34,000- and 28,000-dalton material from 125I-labeled extracts of Raji, but L227 precipitates 25,000-dalton material as well. Immunodepletion experiments confirm that the antibodies react with two different populations of molecules.


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C. Hitzel, U. Gruneberg, M. van Ham, J. Trowsdale, and N. Koch
Sodium Dodecyl Sulfate-Resistant HLA-DR ""Superdimer"" Bands Are in Some Cases Class II Heterodimers Bound to Antibody
J. Immunol., April 15, 1999; 162(8): 4671 - 4676.
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 J. Immunol.Home page
W. P. Thayer, L. Ignatowicz, D. A. Weber, and P. E. Jensen
Class II-Associated Invariant Chain Peptide-Independent Binding of Invariant Chain to Class II MHC molecules
J. Immunol., February 1, 1999; 162(3): 1502 - 1509.
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 Am. J. Respir. Crit. Care Med.Home page
P. WEYNANTS, J. THONNARD, M. MARCHAND, M. DELOS, T. BOON, and P. G. COULIE
Derivation of Tumor-specific Cytolytic T-Cell Clones from Two Lung Cancer Patients with Long Survival
Am. J. Respir. Crit. Care Med., January 1, 1999; 159(1): 55 - 62.
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 Clin. Cancer Res.Home page
G. Strau{beta}, B. Guckel, D. Wallwiener, and G. Moldenhauer
Without Prior Stimulation, Tumor-associated Lymphocytes from Malignant Effusions Lyse Autologous Tumor Cells in the Presence of Bispecific Antibody HEA125xOKT3
Clin. Cancer Res., January 1, 1999; 5(1): 171 - 180.
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 J. Immunol.Home page
L. Lem, D. A. Riethof, M. Scidmore-Carlson, G. M. Griffiths, T. Hackstadt, and F. M. Brodsky
Enhanced Interaction of HLA-DM with HLA-DR in Enlarged Vacuoles of Hereditary and Infectious Lysosomal Diseases
J. Immunol., January 1, 1999; 162(1): 523 - 532.
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 J. Immunol.Home page
R. A. Ettinger, A. W. Liu, G. T. Nepom, and W. W. Kwok
Exceptional Stability of the HLA-DQA1*0102/DQB1*0602 {alpha}{beta} Protein Dimer, the Class II MHC Molecule Associated with Protection from Insulin-Dependent Diabetes Mellitus
J. Immunol., December 1, 1998; 161(11): 6439 - 6445.
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 J. Immunol.Home page
J. Brogdon, D. D. Eckels, C. Davies, S. White, and C. Doyle
A Site for CD4 Binding in the {beta}1 Domain of the MHC Class II Protein HLA-DR1
J. Immunol., November 15, 1998; 161(10): 5472 - 5480.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
D. S. Bradley, P. Das, M. M. Griffiths, H. S. Luthra, and C. S. David
HLA-DQ6/8 Double Transgenic Mice Develop Auricular Chondritis Following Type II Collagen Immunization: A Model for Human Relapsing Polychondritis
J. Immunol., November 1, 1998; 161(9): 5046 - 5053.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
C. Hammond, L. K. Denzin, M. Pan, J. M. Griffith, H. J. Geuze, and P. Cresswell
The Tetraspan Protein CD82 Is a Resident of MHC Class II Compartments Where It Associates with HLA-DR, -DM, and -DO Molecules
J. Immunol., October 1, 1998; 161(7): 3282 - 3291.
[Abstract] [Full Text] [PDF]

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 J. Virol.Home page
X. Wang, W. J. Kenyon, Q. Li, J. Mullberg, and L. M. Hutt-Fletcher
Epstein-Barr Virus Uses Different Complexes of Glycoproteins gH and gL To Infect B Lymphocytes and Epithelial Cells
J. Virol., July 1, 1998; 72(7): 5552 - 5558.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
E. Stang, C. B. Guerra, M. Amaya, Y. Paterson, O. Bakke, and E. D. Mellins
DR/CLIP (Class II-Associated Invariant Chain Peptides) and DR/Peptide Complexes Colocalize in Prelysosomes in Human B Lymphoblastoid Cells
J. Immunol., May 15, 1998; 160(10): 4696 - 4707.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
C. B. Guerra, R. Busch, R. C. Doebele, W. Liu, T. Sawada, W. W. Kwok, M.-d. Y. Chang, and E. D. Mellins
Novel Glycosylation of HLA-DR{alpha} Disrupts Antigen Presentation Without Altering Endosomal Localization
J. Immunol., May 1, 1998; 160(9): 4289 - 4297.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
K. A. Muczynski, S. K. Anderson, and D. Pious
Discoordinate Surface Expression of IFN-{gamma}-Induced HLA Class II Proteins in Nonprofessional Antigen-Presenting Cells with Absence of DM and Class II Colocalization
J. Immunol., April 1, 1998; 160(7): 3207 - 3216.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
C. Saudrais, D. Spehner, H. de la Salle, A. Bohbot, J.-P. Cazenave, B. Goud, D. Hanau, and J. Salamero
Intracellular Pathway for the Generation of Functional MHC Class II Peptide Complexes in Immature Human Dendritic Cells
J. Immunol., March 15, 1998; 160(6): 2597 - 2607.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
R. Busch, R. C. Doebele, E. von Scheven, J. Fahrni, and E. D. Mellins
Aberrant Intermolecular Disulfide Bonding in a Mutant HLA-DM Molecule: Implications for Assembly, Maturation, and Function
J. Immunol., January 15, 1998; 160(2): 734 - 743.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
G. Aichinger, L. Karlsson, M. R. Jackson, M. Vestberg, J. H. Vaughan, L. Teyton, R. I. Lechler, and P. A. Peterson
Major Histocompatibility Complex Class II-dependent Unfolding, Transport, and Degradation of Endogenous Proteins
J. Biol. Chem., November 14, 1997; 272(46): 29127 - 29136.
[Abstract] [Full Text] [PDF]

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 JEMHome page
S. P. Fling, J. Rak, K. A. Muczynski, B. Arp, and D. Pious
Novel Mutants Define Genes Required for the Expression of Human Histocompatibility Leukocyte Antigen DM: Evidence for Loci on Human Chromosome 6p
J. Exp. Med., November 3, 1997; 186(9): 1469 - 1480.
[Abstract] [Full Text] [PDF]

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 ScienceHome page
L. K. Denzin, D. B. Sant'Angelo, C. Hammond, M. J. Surman, and P. Cresswell
Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing
Science, October 3, 1997; 278(5335): 106 - 109.
[Abstract] [Full Text]

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 BloodHome page
R. Cantin, J.-F. Fortin, G. Lamontagne, and M. Tremblay
The Acquisition of Host-Derived Major Histocompatibility Complex Class II Glycoproteins by Human Immunodeficiency Virus Type 1 Accelerates the Process of Virus Entry and Infection in Human T-Lymphoid Cells
Blood, August 1, 1997; 90(3): 1091 - 1100.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
L. Lightstone, R. Hargreaves, G. Bobek, M. Peterson, G. Aichinger, G. Lombardi, and R. Lechler
In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM
PNAS, May 27, 1997; 94(11): 5772 - 5777.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
A Simonsen, E Stang, B Bremnes, M Roe, K Prydz, and O Bakke
Sorting of MHC class II molecules and the associated invariant chain (Ii) in polarized MDCK cells
J. Cell Sci., January 3, 1997; 110(5): 597 - 609.
[Abstract] [PDF]

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 JEMHome page
L. K. Denzin, C. Hammond, and P. Cresswell
HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules
J. Exp. Med., December 1, 1996; 184(6): 2153 - 2166.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. Salamero, R. Le Borgne, C. Saudrais, B. Goud, and B. Hoflack
Expression of Major Histocompatibility Complex Class II Molecules in HeLa Cells Promotes the Recruitment of AP-1 Golgi-specific Assembly Proteins on Golgi Membranes
J. Biol. Chem., November 29, 1996; 271(48): 30318 - 30321.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. R. Newcomb, C. Carboy-Newcomb, and P. Cresswell
Trimeric Interactions of the Invariant Chain and Its Association with Major Histocompatibility Complex Class II alpha beta Dimers
J. Biol. Chem., September 27, 1996; 271(39): 24249 - 24256.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. Sugita and M. B. Brenner
Association of the Invariant Chain with Major Histocompatibility Complex Class I Molecules Directs Trafficking to Endocytic Compartments
J. Biol. Chem., January 20, 1995; 270(3): 1443 - 1448.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. Arimilli, C. Cardoso, P. Mukku, V. Baichwal, and B. Nag
Refolding and Reconstitution of Functionally Active Complexes of Human Leukocyte Antigen DR2 and Myelin Basic Protein Peptide from Recombinant alpha and beta Polypeptide Chains
J. Biol. Chem., January 13, 1995; 270(2): 971 - 977.
[Abstract] [Full Text] [PDF]

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 BMJHome page
R Y M Tun, M Peakman, L Alviggi, M J Hussain, S S S Lo, M Shattock, D A Pyke, G F Bottazzo, D Vergani, and R D G Leslie
Importance of persistent cellular and humoral immune changes before diabetes develops: prospective study of identical twins
BMJ, April 23, 1994; 308(6936): 1063 - 1068.
[Abstract] [Full Text]

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 J. Cell Sci.Home page
S. Zachgo, B. Dobberstein, and G. Griffiths
A block in degradation of MHC class II-associated invariant chain correlates with a reduction in transport from endosome carrier vesicles to the prelysosome compartment
J. Cell Sci., November 1, 1992; 103(3): 811 - 822.
[Abstract] [PDF]

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 Cold Spring Harb Symp Quant BiolHome page
F.M. Brodsky, B. Koppelman, J.S. Blum, M.S. Marks, P. Cresswell, and L. Guagliardi
Intracellular Colocalization of Molecules Involved in Antigen Processing and Presentation by B Cells
Cold Spring Harb Symp Quant Biol, January 1, 1989; 54(0): 319 - 331.
[Abstract] [PDF]

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 Cold Spring Harb Symp Quant BiolHome page
M.E.F. Smith, J.G. Bodmer, A.P. Kelly, J. Trowsdale, S.C. Kirkland, and W.F. Bodmer
Variation in HLA Expression on Tumors: An Escape from Immune Response
Cold Spring Harb Symp Quant Biol, January 1, 1989; 54(0): 581 - 586.
[Abstract] [PDF]

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 Arch DermatolHome page
V. B. Morhenn, K. Pregerson-Rodan, R. H. Mullen, G. S. Wood, B. J. Nickoloff, S. A. Sherwin, and E. M. Farber
Use of Recombinant Interferon Gamma Administered Intramuscularly for the Treatment of Psoriasis
Arch Dermatol, December 1, 1987; 123(12): 1633 - 1637.
[Abstract] [PDF]

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 Arch DermatolHome page
D. G. Deneau, G. S. Wood, J. Beckstead, R. T. Hoppe, and N. Price
Woringer-Kolopp Disease (Pagetoid Reticulosis) Four Cases With Histopathologic, Ultrastructural, and Immunohistologic Observations
Arch Dermatol, August 1, 1984; 120(8): 1045 - 1051.
[Abstract] [PDF]

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 Arch Intern MedHome page
R. D. deShazo, J. P. Penico, G. A. Pankey, J. A. Nordberg, J. L. Newton, B. Bozelka, L. M. Cortez, and J. R. Dalovisio
Studies in Homosexual Patients With and Without Lymphadenopathy: Relationships to the Acquired Immune Deficiency Syndrome
Arch Intern Med, June 1, 1984; 144(6): 1153 - 1158.
[Abstract] [PDF]

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 ANN INTERN MEDHome page
R. D. deSHAZO, W. A. ANDES, J. NORDBERG, J. NEWTON, C. DAUL, and B. BOZELKA
An Immunologic Evaluation of Hemophiliac Patients and Their Wives: Relationships to the Acquired Immunodeficiency Syndrome
Ann Intern Med, August 1, 1983; 99(2): 159 - 164.
[Abstract] [PDF]


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