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The Qa-2 Antigen on Lymphocyte Subpopulations. Mixed Lymphocyte Culture and Cell-Mediated Lympholysis¹

From the Division of Laboratories and Research, New York State Department of Health, Albany, New York 12201

Abstract

Treatments of spleen cells from Qa-2⁺ strains with Qa-2 antiserum plus complement (C) have revealed that the Qa-2 antigen is present on restricted functional lymphocyte subpopulations. Anti-Qa-2 plus C reduced the mixed lymphocyte culture response and inhibited the generation of cytolytic effector cells. This treatment, however, did not affect cytolytic effector cells once they were generated.

Footnotes

¹ This work was supported in part by National Institutes of Health Research Grant No. AI 12603 awarded by the National Institute of Allergy and Infectious Diseases, Public Health Service, Department of Health, Education, and Welfare.

² Present address: Department of Pathology and Microbiology, West Virginia University Medical Center, Morgantown, West Virginia 26506.

³ Reprint requests should be directed to Dr. Lorraine Flaherty, Division of Laboratories and Research, New York State Department of Health, Albany, New York 12201.