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Immunopotentiating Effects of Amphotericin B

I. Enhanced Contact Sensitivity in Mice¹

From the Departments of Microbiology and Immunology and of Medicine at The Jewish Hospital of St. Louis, Washington University School of Medicine, St. Louis, Missouri 63110

Abstract

Contact sensitivity responses to dinitrofluorobenzene (DNFB) or oxazolone were enhanced by amphotericin B (AmB) administration. This adjuvant effect of AmB was documented in mice by ear thickness measurements, ear histology, and the 5-iodo-2'-deoxyuridine-¹²⁵I ear assay. The optimum immunopotentiating effect of AmB required its simultaneous administration at the time of skin sensitization. AmB-induced adjuvant effects were also observed in adoptive transfer experiments in which syngeneic recipients of lymph node cells from animals sensitized with DNFB plus AmB gave stronger contact sensitivity responses than recipients of cells from mice sensitized with DNFB alone. AmB also interfered with tolerance induction by i.v. dinitrobenzene sulfonic acid, suggesting that its adjuvant effects involve inhibition of suppressor cells or their precursors.

Footnotes

¹ This work was supported by National Institutes of Health Grants PO1 CA 15665 and 5 T32 CA 09118.