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Structural Studies on the Murine Ia Alloantigens

VI. Evidence That Both Subunits of the I-A Alloantigen Are Encoded by the I-A Subregion¹

From the Department of Microbiology, The University of Texas Health Science Center, Southwestern Medical School, Dallas, Texas 75235

Abstract

The and subunits of the murine I-A alloantigens from several H-2 haplotypes were examined by comparative tryptic peptide mapping by using double label (³H and ¹⁴C) techniques. Significant structural variation between alleles was detected in both subunits. Tryptic digests of the polypeptides from s, b, and d showed only 65% co-elution with k; -chains from s, b, d, and r were about 50% similar to the k subunit. Peptide analysis of the A^k subunits from intra-H-2 recombinant strains indicated that both the and polypeptides are encoded within the I-A subregion.

Footnotes

¹ This work was supported by National Institutes of Health Grants AI-12127, AI-13448, AI-11851, AI-10967, AI-12796, AI-14742; National Science Foundation Grant PCM-22411; and American Cancer Society Grant IM-140.

² RGC is a recipient of NIH Postdoctoral Fellowship AI-05702.