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The Journal of Immunology, 1979, 123: 2709-2715.
Copyright © 1979 by The American Association of Immunologists, Inc.
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Regulation of Antibody Response in Different Immunoglobulin Classes

VI. Selective Suppression of IgE Response by Administration of Antigen-Conjugated Muramylpeptides1

Tadamitsu Kishimoto, Yoshikatsu Hirai2, Kenji Nakanishi, Ichiro Azuma3, Atsuo Nagamatsu4 and Yuichi Yamamura

From the Third Department of Internal Medicine, Osaka University Medical School, Fukushima-ku, Osaka, Japan

Abstract

The suppressive effect of antigen-conjugated muramylpeptides or 6-O-mycoloyl muramylpeptides selectively on the induction of IgE antibody response was demonstrated. Preadministration of DNP-mycoloyl muramylpeptides completely inhibited the induction of the anti-DNP IgE antibody response with DNP-ovalbumin (DNP-OA). The selective suppression of the IgE response was due to the induction of DNP-specific suppressor T cells by DNP-mycoloyl muramylpeptides, and the suppressor cells were shown to be radiosensitive. Preadministration of OA-conjugated muramylpeptides partially inhibited the primary and secondary induction of an anti-OA IgE antibody response. The suppressor effect was also due to the induction of OA-specific suppressor T cells. Application of allergen-conjugated muramylpeptides as therapeutic agents in human allergic diseases was suggested.

Footnotes

1 This work was supported by a Grant-in-Aid for immunologic research from the Ministry of Education, Science and Culture, Japan.

2 Present address: The Department of Biology, Brandeis University, Waltham, Massachusetts 02154.

3 Present address: The Institute of Immunological Science, Hokkaido University, Sapporo, Japan.

4 Present Address: The Department of Biochemistry, Fukuoka University School of Pharmaceutical Science, Fukuoka, Japan.






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