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Imbalances of T Cell Subpopulations in Patients with Atopic Diseases and Effect of Specific Immunotherapy¹

From the Instituto Scientifico di Medicina Interna and Istituto di Microbiologia, University of Genova, 16132, Genova, Italy

Abstract

Reduced numbers of T cells with Fc receptors for IgG (T_G cells) are present in blood samples of patients with respiratory allergic disease, mainly those with severe symptoms, T_G cells have been previously shown to be suppressor in the pokeweed mitogen- (PWM) dependent B cell differentiation. T cells with Fc receptor for IgM (T_M cells), which help immunoglobulin production, are in a normal range. After specific hyposensitization, resulting in a sharp improvement of clinical symptoms, T_G cell subset reached normal values.

Footnotes

¹ This work was partially supported by Grant CNR 78.02850.96.

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