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Lyt Phenotypes of Responding Cells in Secondary Alloantigen Responses¹

From the Immunobiology Research Center and Department of Medical Genetics and Surgery, University of Wisconsin, Madison, Wisconsin 53706

Abstract

Lymphocytes responding in a "secondary" MLC-CML system, after in vitro sensitization, apparently fall into two classes with regard to their Lyt phenotype. First, are the cells that form the majority of the proliferating cells after restimulation with either I or K + I differences, which are Lyt 1^-2^-, and second, are T_c that are Lyt 1^-2⁺. The Lyt 1^-2^- proliferating cells are not cytotoxic and are lysed by treatment with anti-Thy 1.2 serum in the presence of C.

Footnotes

¹ This work was supported by National Institutes of Health Grants AI 08439, CA 16836, and AI 15588. This is Paper NO. 201 from the Immunobiology Research Center and Paper No. 2370 from the Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706.