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Sex-Related Immunocompetence of BALB/c Mice

I. Study of Immunologic Responsiveness of Neonatal, Qeanling, and Young Adult Mice¹

From Rutgers-The State University of New Jersey, Department of Zoology/Physiology, Newark, New Jersey and the University of Texas Medical Branch, Division of Biochemistry, Galveston, Texas

Abstract

The responses of lymphoid cells from the thymus, lymph nodes, and spleen of male and female BALB/c mice were evaluated to determine if sex-related variations in immune expression could be found. Immunologic assays used included blastogenic responses to mitogens, mixed lymphocyte responses, and direct and indirect measurement of plaque-forming cells against soluble and particulate antigens. The results indicated that responses of spleen cells from young adult female mice were higher than those of males in all comparative tests. Little or no differences between the sexes were observed in the mitogenesis of lymph nodes and thymuses. Newborn mice did not demonstrate the sex-associated immune differences. Among the weanling mice slight differences between male and female spleen cells responsiveness to mitogenic agents were observed.

Footnotes

¹ This work was supported in part by the Charles and Johanna Busch Foundation Grant RR 7059.

² Present address: University of California at Los Angeles, Department of Microbiology, Los Angeles, California 90024.

³ Present address: George Washington University, Department of Biochemistry, Washington, D. C. 20037.

⁴ Present address: University of California at Los Angeles, Laboratory of Nuclear Medicine and Radiation Biology, Warren Hall, Los Angeles, California 90024.

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