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Functional Differentiation of T Cell Precursors

I. Parameters of Carrier-Specific Tolerance in Murine Helper T Cell Precursors¹

From the Division of Immunology, Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710

Abstract

Irradiated mice reconstituted with bone marrow from sheep -globulin- (SGG) tolerant syngeneic donors display reduced IgG responsiveness to challenge with trinitrophenylated (TNP)-SGG compared with recipients of normal marrow. This effect is SGG-specific and is due neither to suppressor T cells nor to antigen carryover. "Helper T cell precursor tolerance" can be induced with as little as 40 µg tolerogen (SGG). Unlike mature helper T cells, these precursors show both a rapid induction and rapid waning patterns, suggesting a high rate of turnover. Our results imply that marrow helper T cell precursors bear antigen-specific receptors and that the T cell repertoire must be at least partially generated before residence in the thymus.

Footnotes

¹ This work was supported by United States Public Health Service Grant AI-10716.

² Supported by United States Public Health Service Training Grant TG-32-CA-09058. Present address: Department of Microbiology and Immunology, University of Oregon Health Sciences Center, Portland, Oregon 97201.

³ Research Career Development Awardee, No. 1 K04-AI-00093, and to whom correspondence should be addressed.