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The Journal of Immunology, 1979, 123: 1795-1798.
Copyright © 1979 by The American Association of Immunologists, Inc.
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Suppression of Adult B Cell Differentiation in Pokeweed Mitogen-Stimulated Cultures by Fc(IgG) Receptor-Negative T Cells from Cord Blood1

Naoki Moriya2, Takeshi Nagaoki, Norihiko Okuda and Noboru Taniguchi

Department of Pediatrics, School of Medicine, Kanazawa University, Kanazawa 920, Japan

Abstract

Unfractionated T lymphocytes from cord blood suppressed adult B cell differentiation into immunoglobulin-producing cells in pokeweed mitogen-stimulated co-culture system. Cord blood T cells were fractionated into T cells bearing Fc receptors for IgG(T{gamma} cells) and T cells lacking Fc receptors for IgG(Tnon-{gamma} cells) by rosette formation with ox erythrocytes coated by the IgG fraction of rabbit antisera followed by Ficoll-Hypaque gradient sedimentation. T{gamma} cells from cord blood, even though isolated after the interaction with immune complexes, showed no suppressor activity on adult B cell differentiation, whereas Tnon-{gamma} cells exerted strong suppression to a similar extent to that by unfractionated cord T cells. The suppressor activity on B cell differentiation by Tnon-{gamma} cells as well as by unfractionated T cells from cord blood was completely abrogated by irradiation with 2000 rads. These results indicated that, contrary to suppressor function found in adult T cells, the suppressor activity in cord T cells might be exerted by a T cell subset lacking Fc receptors for IgG(Tnon-{gamma} cells).

Footnotes

1 This work was supported in part by grants from the Ministry of Welfare and from the Ministry of Education of Japan.

2 Address correspondence to: Dr. Naoki Moriya, Department of Pediatrics, School of Medicine, Kanazawa University, Kanazawa 920, Japan.






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