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Terminal Transferase-Positive Human Bone Marrow Cells Exhibit the Antigenic Phenotype of Common Acute Lymphoblastic Leukemia¹

Department of Immunology, Royal Free Hospital, London, the Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20014, the Department of Surgery, Radcliffe Infirmary, Oxford, the Department of Haematology, Institute of Child Health, London, and the Membrane Immunology Laboratory, Imperial Cancer Research Fund, London

Abstract

Combined immunologic assays for TdT enzyme and membrane markers show that TdT⁺ cells in nonleukemic human bone marrow carry ALL-associated and Ia-like antigens but no thymocyte markers or surface Ig. These cells could be precursors involved in acute lymphoblastic leukemia of the "common" or non-T, non-B type and in lymphoid blast crisis of Ph' positive chronic myeloid leukemia. A few TdT⁺, Ia⁺ cells express cytoplasmic IgM, indicating that some pre-B cells may be TdT positive.

Footnotes

¹ This work was supported in part by Grant CA-23262 from the National Cancer Institute (to F. J. B.), and by a Travelling Fellowship from the New South Wales State Cancer Council of Australia (to K. F. B.).

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