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Antibody-Mediated Immunosuppression of a Cytotoxic Cell Response Not Involving a Simple Antigen-Masking Mechanism¹

Department of Microbiology and Immunology, University of Western Ontario, London, Ontario N6A 5C1

Abstract

An in vitro cytotoxic cell response against alloantigens was inhibited by antibody directed against the alloantigens and also by anti-trinitrophenyl antibody provided that the allogeneic stimulator cells were modified with trinitrophenyl. Inhibition of an anti-allogeneic cytotoxic cell response against trinitrophenyl-coupled allogeneic stimulator cells by anti-trinitrophenyl antibody is dependent upon the intact Fc portion of inhibitory antibody. The magnitude of the difference between intact and F(ab')₂ anti-trinitrophenyl antibody in immunosuppressive activity suggests that the Fc portion emits negative signals rather than simply adding to a steric hindrance effect.

Footnotes

¹ This work was supported by grants from The National Cancer Institute and The Medical Research Council of Canada.