HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Araneo, B. A. Articles by Sercarz, E. E. Search for Related Content PubMed Articles by Araneo, B. A. Articles by Sercarz, E. E.

Ir Gene Defects May Reflect a Regulatory Imbalance

I. Helper T Cell Activity Revealed in a Strain Whose Lack of Response Is Controlled by Suppression¹

Department of Microbiology, University of California, Los Angeles, Los Angeles, California 90024

Abstract

A singular responsiveness to HEL was revealed in a peripheral lymphoid compartment of the genetically nonresponsive H-2^b mouse. Although i.p. injection of HEL induces suppression and a lack of anti-HEL production, following footpad injection there is an early emergence in the popliteal lymph node (P-LN) of HEL-specific helper activity and plaque-forming cells. Furthermore, the early P-LN transiently expresses one of two T cell types needed for initiation of suppression. Delayed recruitment of the second required cell-type permits the induction of efficient suppression. There is only a short period during which there is concurrent representation of the two T cell subpopulations, and by mixing early and late deficient P-LN T cells, suppression could be established. The general implication of these results is that although a vigorous helper cell potential may exist in a strain nonresponsive to a multideterminant antigen, it can be obscured by a regulatory cell imbalance that results in the manifestation of a generalized Ir gene "defect."

Footnotes

¹ This work was supported by Grants CA-24442 and AI-11183 from the National Institutes of Health.

² B. A. was the recipient of a Postdoctoral National Institutes of Health Fellowship.

This article has been cited by other articles:

				R. Sealy, W. Chaka, S. Surman, S. A. Brown, P. Cresswell, and J. L. Hurwitz Target Peptide Sequence within Infectious Human Immunodeficiency Virus Type 1 Does Not Ensure Envelope-Specific T-Helper Cell Reactivation: Influences of Cysteine Protease and Gamma Interferon-Induced Thiol Reductase Activities Clin. Vaccine Immunol., April 1, 2008; 15(4): 713 - 719. [Abstract] [Full Text] [PDF]