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The Journal of Immunology, 1979, 123: 1371-1375.
Copyright © 1979 by The American Association of Immunologists, Inc.
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Studies on the Kinetics of Hemopoietic Stem Cells and Immune Responses to the Hapten-Carrier Conjugate1

Teruaki Hamano, Shunro Kai, Shigeru Fujita and Kiyoyasu Nagai

Second Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663, Japan

Abstract

The correlation between the kinetics of hemopoietic stem cells and immune responses to the hapten-carrier conjugate was investigated. The numbers of both pluripotent stem cells (CFU-S) and myeloid stem cells (CFU-C) in the spleen from mice immunized with the hapten-carrier conjugate were significantly greater than those of the control and the activity of colony-stimulating factor (CSF) in the serum of these mice was markedly elevated. The supernatant of short-term incubation of splenic T lymphocytes from these mice, when stimulated with carrier protein, had high levels of both activities of CSF and helper T cell factors. The study by gel chromatography showed that these factors are similar m.w. substances of 35,000 to 45,000 daltons. But analysis by ion-exchange chromatography demonstrated that they do not have identical biochemical properties. The present studies suggest that biologically active factors produced by T cells stimulated with carrier protein may induce the enhancing effect on the proliferation and differentiation of hemopoietic stem cells and immune responses to the hapten-carrier conjugate.

Footnotes

1 This work was supported by Grant-in-Aid 357255 from the Ministry of Education, Science and Culture, Japan, and from the Ministry of Health and Welfare, Japan, for idiopathic hematological disorders.






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