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Passive Enhancement of Mouse Tumor Allografts by Alloantibodies Is Fc-Dependent¹

Department of Pathology and the Department of Medicine, Division of Nephrology, University of Nijmegen, Nijmegen, The Netherlands

Abstract

Enhancement of growth of a B10.D2 fibrosarcoma in B6AF₁ recipients could be induced by administration of B6AF₁ anti-B10.D2 lymphocyte serum. The role of the Fc part in this phenomenon was studied by treatment of the B6AF₁ recipients with F(ab')₂ fragments of enhancing alloantibodies. A highly purified F(ab')₂ preparation was used to exclude any effects of undigested IgG. Administration of F(ab')₂ did not lead to enhancement of the tumor allografts, not even when given in a dose that was 22 times the molar amount of the lowest enhancing dose of undigested IgG. We therefore conclude that passive enhancement of mouse tumor allografts by alloantibodies is Fc dependent.

Footnotes

¹ This work was supported in part by the Netherlands Foundation for Medical Research (FUNGO) and the Netherlands Kidney Foundation.

² Mailing address: Department of Pathology, University of Nijmegen, Geert Grooteplein Zuid 24, 6500 HB Nijmegen, The Netherlands.