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The Cytolytic T Lymphocyte Response to Trinitrophenyl-Modified Syngeneic Cells

I. Evidence for Antigen-Specific Helper T Cells¹

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

Mice were primed subcutaneously with trinitrophenyl (TNP)-modified syngeneic spleen cells. Seven days later, spleen cells from these in vivo primed mice, or spleen cells from naive mice, were co-cultured with TNP-modified syngeneic cells. Spleen cells from the in vivo primed mice demonstrated augmented cytolytic T lymphocyte (CTL) activity. The spleens of these in vivo primed mice contained a population of radioresistant, antigen-specific, helper T cells. Specifically, spleen cells from these mice, after x-irradiation, were able to augment the in vitro CTL response of normal spleen cells to TNP-modified syngeneic cells.

Footnotes

¹ This work was supported by United States Public Health Service Grants CA-14723 and T32 AI-07061-03.