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The Carboxy-Terminal Peptides of in vitro Precursor and in vivo Mature Light Chains Are Identical¹

Department of Microbiology, University of Virginia, School of Medicine, Charlottesville, Virginia 22908

Abstract

Protein structural analysis of several precursor light chains indicates that these in vitro products include a cysteine-containing tryptic peptide that is indistinguishable from the carboxy-terminal tryptic tripeptide present in in vivo mature light chains. It is concluded that although in vitro precursor light chains contain an additional amino-terminal sequence, their carboxy-terminus is the same as that found in in vivo mature light chains.

Footnotes

¹ This work was supported by National Institutes of Health Grant AI-12525 from the national Institutes of Health, Bethesda, Maryland.

² Present address: Department of Microbiology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110.