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Selective Localization of Radiolabeled Immune Lymphocytes into Syngeneic Tumors¹

From the Division of Tumor Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, and the Departments of Microbiology and Immunology, Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195

Abstract

Newly formed long-lived small lymphocytes (LLSL) generated during the immunization of mice to tumor specific transplantation antigens (TSTA) of syngeneic MCA-induced sarcomas were labeled. We then studied the localization of these labeled cells into tumor implants. "Criss-cross" experiments were performed in which MCA sarcomas with individually distinct TSTA were studied in parallel. A selective localization of LLSL into tumors to which the lymphocytes were immune was found when small tumor pieces were implanted into immune mice whose LLSL had been labeled. Selective localization was also detected upon adoptive transfer of immune LLSL to tumor-bearing mice, but only when these mice had, before transfer, received a sublethal dose of whole body irradiation.

Footnotes

¹ This work was supported by Grants CA 19148, CA 19149, and CA 06244-01 from the National Institutes of Health, by grant IM-431 from the American Cancer Society, and by ERDA Contract AT (45-1)-2225.

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