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Ontogeny of the Ferret Humoral Immune Response¹

From the Department of Pathology, UCLA School of Medicine, Los Angeles, California 90024 and the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205

Abstract

Infant ferrets are born with nearly undetectable immunoglobulin levels, but by 9 days of age the infant ferret serum contains 77, 29, and 13% of adult mean serum levels of IgG, IgA, and IgM. Transmucosal uptake of IgG by the infant ferret occurred for the first 30 days of life. The specific anti-respiratory syncytial virus neutralizing titer of whole milk was 5.5 times higher than maternal serum despite a lower concentration of immunoglobulins in the milk.

Footnotes

¹ This work was supported by Public Health Service Contract NO1-AI-52517 and Fellowship 1F32-AI-00422 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health.