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Immune Response Gene Control of Determinant Selection

II. Genetic Control of the Murine T Lymphocyte Proliferative Response to Insulin

From the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The genetic control of the murine T cell proliferative response to insulin was examined. It was found for two responder strains of mice that each recognizes a different determinant on the insulin molecule. H-2^b mice recognize a determinant in the A chain loop of insulin whereas H-2^d mice recognize a determinant that resides in the B chain, possibly in the last eight amino acids. Using H-2 recombinant strains of mice, the location of Ir gene control of the response to both determinants was mapped to the K region and/or I-A subregion of H-2. The possibility of non-MHC regulation of MHC-controlled immune responses is suggested by studies of recombinant inbred strains of mice.

Footnotes

¹ Present address: Federal University of Rio de Janerio, Brazil.

² Correspondence: Department of Immunology, Merck Institute for Therapeutic Research, P.O. Box 2000, Rahway, New Jersey 07065.

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