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From the Department of Immunology and Microbiology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, Michigan 48201 and the Department of Immunology, Mayo Medical School, Rochester, Minnesota 55901
Abstract
Studies were initiated to define the H-2-linked genetic control of response to self-determinants of MTg. In addition to the Ir gene control of H-2K end, a modifying effect of D end was seen. The extent of regulation depended upon the derivation of the K-end Ir-Tg gene(s) as well as the D-end genes. When the Ir-Tg gene was from good responder H-2k and H-SS strains, and the H-2D-end gene from the d allele, antibody levels were moderate to high but cellular infiltration was significantly reduced. These findings demonstrate genetic interaction between I-region and D-end gene products in the response to a self-antigen, MTg.
Footnotes
1 This work was supported by Public Health Service Grants CA 18900 and AM 20023 from the National Institutes of Health.
2 Present address: Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
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