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Immunoprophylaxis of Respiratory Syncytial Virus Infection in the Infant Ferret¹

From the Department of Pathology, UCLA School of Medicine, Los Angeles, California 90024 and the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205

Abstract

Infant ferrets can be protected from respiratory syncytial virus challenge at 3 days of age by gestational infection of their mothers. Ferrets acquire their immunity to respiratory syncytial virus postpartum via immunizing products of lactation. The level of protection against viral replication correlates with the maternal serum neutralizing titer or a concomitant factor. Passive administration of adult ferret serum with a neutralizing titer of 1:1024 or greater, either i.p. or orally does not confer immunity. A nonantibody-mediated protective mechanism appears to play an important role in protecting the infant ferret from respiratory syncytial virus replication. Our findings allow the testing of the efficacy of future human vaccines before human clinical trial.

Footnotes

¹ This work was supported by Public Health Service Contract N01-AI-52517 and Fellowship 1F32-AI-00422 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health. Computing assistance was obtained from the Health Sciences Computing Facility, UCLA, sponsored by NIH special research resources Grant RR-3.

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