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Expression of MHC Antigens by Mouse Thymic Dendritic Cells¹

From the Laboratory for Experimental Oncology, Department of Pathology, and the Departments of Genetics and Medicine/Immunology, Stanford University School of Medicine, Stanford, California 94305

Abstract

Thymic epithelial cells express MHC antigens in several different patterns. I-A is present throughout the thymic cortex on dendritic cells. The remainder of the I region and H-2K/D are expressed on dendritic cells apparently only variably in the cortex (at least in some haplotypes). All MHC antigens tested are present in the medulla on epithelial cells; expression on medullary lymphocytes cannot be evaluated. Monoclonal anti-MHC antibodies confirm these results. The significance of these findings to T cell maturation is discussed.

Footnotes

¹ This work was supported in part by United States Public Health Service Grant AI-09072. A portion of this work was presented at the Federation of American Societies for Experimental Biology meeting in Atlanta, Georgia, June 8, 1978, Abstract number 2146.

² Postdoctoral Fellow, United States Public Health Service Pathobiology Training Grant GM-02236 and NIH Grant 5 P01 CA 05838.

³ Fogarty Postdoctoral Fellow, United States Public Health Service.

⁴ NSF Postdoctoral Fellow.

⁵ Faculty Research Awardee, American Cancer Society.

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