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Binding Studies with Antibodies Having Phosphorylcholine Specificity and Fragments Derived from Their Homologous Streptococcus Pneumoniae Type 27 Capsular Polysaccharide¹

From the National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The capsular polysaccharide from Streptococcus pneumoniae type 27 (S-27) has been fragmented into oligosaccharides by controlled degradations. Binding of these derived small ligands with heterogeneous rabbit anti-S-27 antibody of selected phosphorylcholine affinity indicates that a major immunodeterminant of S-27 is the phosphorylcholine moiety, but that these anti-P.C. antibodies are also capable of binding to the polysaccharide backbone from which the P.C. has been removed.

Footnotes

¹ Dedicated to Donald R. Boelke, M.D.

² Staff Fellow 1977 to present.

³ To whom correspondence should be sent.