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Variations in Expression of Xenotropic Murine Leukemia Virus Genomes in Lymphoid Tissues of NZB Mice

From the Laboratory of Microbial Immunity and Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases; Laboratory of Microbiology and Immunology, National Institute for Dental Research; and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Lymphocytes from Thy, Sp, LN, and BM of NZB mice were tested for expression of X-MuLV genomes as cell surface gp70 (XenCSA) or infectious virus. The results demonstrate major dissociations for these parameters of X-MuLV expression in different lymphoid compartments and suggest that factors involved in T lymphocyte differentiation modify the levels of expression in these two modes.

Footnotes

¹ Address reprint requests to Dr. H. C. Morse III, Building 5, Room 225, N.I.H., Bethesda, Maryland 20014.