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Hanganutziu-Deicher Antigen and Antibody in Pathologic Sera and Tissues¹

From the Department of Microbiology, State University of New York, at Buffalo, School of Medicine, Buffalo, New York 14214

Abstract

Heterophile, Hanganutziu-Deicher (H-D) antigen was studied in pathologic sera by means of inhibition of agglutination of bovine erythrocytes by H-D antibodies. H-D antigen was demonstrated in 38% of random cancer sera, 25% of lymphoma or leukemia sera, 25% of leprosy sera, 8% of infectious mononucleosis sera, 6% of rheumatoid arthritis sera, and 27% of synovial fluids of rheumatoid arthritis patients. None of 134 normal human sera gave positive results. Some of the inhibition-positive cancer sera formed precipitation lines with H-D antibody-containing sera. Over 50% of various extracts of cancer tissues as well as spleens of lymphoma or leukemia patients were shown to contain H-D antigen by means of the inhibition test.

Footnotes

¹ This work was supported by Research Grant IM-24C from the American Cancer Society, and the Richard W. and Mae Stone Goode Estate.

² Please address all correspondence to Dr. F. Milgrom, Department of Microbiology, 203 Sherman Hall, State University of New York at Buffalo, Buffalo, New York 14214.

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